In this study, the extent to which different climate scenarios influence overheating risk, energy use and peak loads for space conditioning of district heated multi-storey buildings in Sweden are explored. Furthermore, the effectiveness of different overheating control measures and the implications of different electricity supply options for space cooling and ventilation are investigated. The analysis is based on buildings with different architectural and energy efficiency configurations including a prefab concrete-frame, a massive timber-frame and a light timber-frame building. Thermal performance of the buildings under low and high Representative Concentration Pathway climate scenarios for 2050-2059 and 2090-2099 are analysed and compared to that under historical climate of 1961-1990 and recent climate of 1996-2005. The study is based on a bottom-up methodology and includes detailed hour-by hour energy balance and systems analyses. The results show significant changes in the buildings' thermal performance under the future climate scenarios, relative to the historical and recent climates. Heating demand decreased significantly while cooling demand and overheating risk increased considerably with the future climate scenarios, for all buildings. In contrast to the cooling demand, the relative changes in heating demand of the buildings under the future climate scenarios are somewhat similar. The changes in the space conditioning demands and overheating risk vary for the buildings. Overheating risk was found to be slightly higher for the massive-frame building and slightly lower for the light-frame building. (C) 2015 Elsevier Ltd. All rights reserved.