Specific photothermal-chemotherapy is a promising tool in the treatment of the cancer. We developed silica-coated Fe3O4 nanoparticles as photothermal agents and magnetic targeting drug delivery system. Doxorubicin-loaded silica-coated Fe3O4 nanoparticles showed pH-responsive release properties. A synthetic antitumor effect of phototherrnal-chemotherapy was realized on MCF-7 cells.