LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

Jiang FJ; Ma S; Xue YB; Hou JQ; Zhang YJ

Biochemical and Biophysical Research Communications, Vol.469, No.4, 985-992, 2016

DOI10.1016/j.bbrc.2015.12.078 Export Citation

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

Jiang FJ, Ma S, Xue YB, Hou JQ, Zhang YJ

Lactate dehydrogenase-A(LDH-A) is an important rate-limiting enzyme in the Warburg effect. Survival analysis indicated poor clinical outcomes in MIBC with high LDH-A expression. The results of in vitro experiment indicated that LDH-A promotes MIBC cells proliferation, invasion and migration. The positive relationship between LDH-A expression and CSC/EMT markers was confirmed both in invasive bladder cell line and in 136 MIBC specimens. Thus, we conclude that LDH-A may be a promising target for MIBC. (C) 2015 Elsevier Inc. All rights reserved.

Keywords:Muscle-invasive bladder cancer;Lactate dehydrogenase-A;Epithelial-to-mesenchymal transition;Histone deacetylases;Oct4;E-cadherin