The aim of this work consists in evaluating the influence of carmabazepine (CBZ) (i) on the endogenous and exogenous respirations, in batch reactors, of bacterial populations taken from a conventional activated sludge process (CAS) and a pilot-scale membrane bioreactor (MBR) and (ii) on COD removal, sludge production and oxygen requirement of a lab-sale MBR system. In batch experiments, the increase in endogenous oxygen needs suggests an increase in maintenance requirements, essentially to manage the chemical stress induced by the CBZ presence. The decrease of exogenous oxygen needs seems to suggest a change in the metabolic pathways of the substrate or a change in the active bacterial species. However, in spite of these momentary changes, no inhibition is observed in the presence of CBZ in the test tank. This result is confirmed by the MBR experiment where no significant difference COD removal, sludge production and oxygen requirement is observed, with and without CBZ. (C) 2010 Elsevier Ltd. All rights reserved.