Two new two-dimensional (2D) Cd(II) coordination compounds constructed from two isomeric thiophenedicarboxylic acid, namely, [Cd(3,4-tdc)](n) (1), [Cd(2,3-tdc)(H2O)](n) (2) (3,4-tdc = 3,4-thiophenedicarboxylate; 2,3-tdc = 2,3-thiophenedicarboxylate), were obtained by the hydrothermal reaction and structurally determined by single-crystal X-ray diffraction. Structural analyses reveal both of them display 2D-layered network, but their detailed structures are clearly different from each other. 1 exhibits a 2D-layered network with a uninodal 4-connectedSP2-periodic(6,3)Id topology, while 2 features a 2D network with 4-connected sql topology. The results indicate the isomeric effect of thiophenedicarboxylates may lead to diverse architectures in the absence of N-donor auxiliary ligands.