In this paper a new original method of synthesis of poly(aspartic acid) (PAA) from aspartic acid (AA) or maleic anhydride under microwave irradiation is presented. The syntheses carried out mainly without the catalyst, received higher yield in comparison for conventional method. PAA has been characterized by nuclear magnetic resonance (1H NMR, 13C NMR), infrared spectroscopy (FT-IR) and termogravimetric analysis (Tg). Obtained polymer we used for several diversified applications, such as, medicine, agriculture and catalyst for oxidation reactions.