Calcium oxalate (CaOx) is the main compound of human kidney stones, specifically calcium oxalate monohydrate crystals (COM). Normal human urine contains small crystals of calcium oxalate dihydrate (COD), which have reduced capacity to form stable aggregates and strong adhesion contacts to renal epithelial cell thus protecting kidney stone formation. Here, we report the preparation of a new monomethylitaconate grafted polymethylsiloxaner, which was able to promote and stabilize COD crystals. Although the mechanisms involved in control of CaOx polymorphism still remain unclear, we believe that research using synthetic polymers would provide interesting chemical clues to develop calculi preventing-compounds.