The title compound 1-benzhydryl-4-(4-chloro-2-fluoro-benzenesulfonyl)-piperazine was synthesized, and structure of the product obtained was confirmed by the X-ray diffraction study. The compound C23H22ClFN2O2S crystallizes in the monoclinic crystal class in the space group P21/c with cell parameters a=9.6180(7), b=12.9670(10), c=19.4020(12), =114.716(3), and Z=4. The structure has been solved by direct methods and refined to R1=0.0440 for 3877 observed reflections with I2(I). The structure reveals that the piperazine ring is in a chair conformation. The geometry around the S atom is distorted tetrahedral.