A variety of liquid crystals with semifluorinated tails including 4-alkoxybenzoic acids (1d-h), 4-alkoxybenzoyl hydrazines (2d-h), and N,N'-bis(4-alkoxybenzoyl) hydrazines (3d-m) have been synthesized, and their properties are compared with their perhydrogenated analogs. Semifluorination in compounds 1d-h suppressed nematic phases, and semifluorinated compounds 2d-h exhibit mesogenic behavior where none is found in their perhydrogenated counterparts. Compounds 3a-c with perhydrogenated chains display Cub and SmC phases. Introduction of one semifluorinated chain, 3d-h suppresses the Cub phase but induces a SmA phase, with lower melting but higher clearing temperatures compared to compounds with two semifluorinated chains, 3i-m. The mesogenic properties of some selected binary mixtures of these compounds 3a-d and some lateral fluoro substituted N,N'-bis (4-alkoxybenzoyl) hydrazines 7-9 are also discussed.