The article presents various behavior aspects of passive and bioactive films on Ti and CoCr alloy and their efficiency in regenerative medicine, taking into account that metallic materials are typically inert, but various surface treatments are devoted to build films which change them into active materials. The studied passive films were oxides and bioactive films with collagen and phosphate coatings. All films were characterized from the point of view of their electrochemical stability. Their composition was evaluated using infrared spectroscopy and electronic microscopy type SEM with and EDAX module The cytotoxicity test for fibroblast growth using direct contact method was the in vitro biocompatibility evaluation for all studied films.