A halogen-anion fluorescent solid-state sensor based on natively porous films doped with a quinolinium derivative is reported. The sensitive films are prepared with a low temperature sol-gel synthesis starting from bridged silsesquioxane precursors, and 6-methoxyquinolinium moieties are covalently linked to the organic-inorganic hybrid network. This sensor system is reversible and allows selective detection and measurement of halogen anion concentrations in the physiological range by a dynamic quenching effect of the sensitive fluorophore. The quenching constants are unaffected by dye inclusion in the bridged polysilsesquioxane matrix. (C) 2016 Elsevier B.V. All rights reserved.