Centrifugal separators have many applications in the separation industry. Comprehensive information based on performance and energy consumption for a detailed comparison between different types of centrifugal separators is essential to allow design optimization and is the focus of this work. A framework for comparing performance with an updated performance chart for four types of centrifugal separators and a comparison with a continuous gravity settling tank is described. A model and chart for performance and energy consumption, which makes it possible to compare different separators, is a key result of this work which extends current available handbooks and guidelines.