Nanostructured hexolites (40/60), (60/40), (80/20) and microstructured hexolite (60/40) powders are pressed by uniaxial compression to obtain explosive charges. This kind of composition is often used for the synthesis of detonation nanodiamonds. The morphology, density and cohesion of the resulting pellets are analyzed in the light of the different used compression parameters. This study allows optimizing the compression parameters to obtain well suited explosive charges from nanostructured explosive components. A good cohesion of the nanostructured explosive pellets could be obtained with increasing the temperature used for the compression. Another very important point is that the nanostructuring of the composites is maintained for every compression.