A large set (60 samples) of oxide systems containing Mo, V, Ti, Zr, Fe, Ni, Co, La, Ce, Al, Si, Sb, Bi, Nb, Sn, and Pb oxides has been obtained by synthesis. It has been found that using Al(OH)(3) (instead of Al2O3) makes it possible to prepare a modified Mo system that ensures a 93-95% selectivity of ethane dehydrogenation to ethylene with a C2H6 conversion as high as 40%. These results open the possibility of purposeful and technologically easy manufacturing of molded systems containing active lattice oxygen, which is able to mediate the oxidative dehydrogenation of ethane to ethylene.