Hexagonal boron nitride (h-BN) is a natural hyperbolic material(1), in which the dielectric constants are the same in the basal plane (epsilon(t) epsilon(x) = epsilon(v)) but have opposite signs (epsilon(t) = epsilon(z) <0) in the normal plane (epsilon(z))(1-4). Owing to this property, finite-thickness slabs of h-BN act as multimode waveguides for the propagation of hyperbolic phonon polaritons(1,2,5)-collective modes that originate from the coupling between photons and electric dipoles(6) in phonons. However, control of these hyperbolic phonon polaritons modes has remained challenging, mostly because their electrodynamic properties are dictated by the crystal lattice of h-BN1,2,7. Here we show, by direct nano-infrared imaging, that these hyperbolic polaritons can be effectively modulated in a van der Waals heterostructure(8) composed of monolayer graphene on h-BN. Tunability originates from the hybridization of surface plasmon polaritons in graphene(9-13) with hyperbolic phonon polaritons in h-BN1,2, so that the eigenmodes of the graphene/h-BN heterostructure are hyperbolic plasmon-phonon polaritons. The hyperbolic plasmon-phonon polaritons in graphene/h-BN suffer little from ohmic losses, making their propagation length 1.5-2.0 times greater than that of hyperbolic phonon polaritons in h-BN. The hyperbolic plasmon-phonon polaritons possess the combined virtues of surface plasmon polaritons in graphene and hyperbolic phonon polaritons in h-BN. Therefore, graphene/h-BN can be classified as an electromagnetic metamaterial(14) as the resulting properties of these devices are not present in its constituent elements alone.