The depletion interaction as induced between colloids by the addition of a polymer depletant is one of. the few ways in which short-ranged attractions between particles can be controlled. Due to These tunable interactions, colloid polymer mixtures have contributed to a better understanding of the role of attractions both in equilibrium phenomena such as phase transitions and liquid surfaces as well as in systems out of equilibrium such as gelation and the glass transition. It is known that, by simple geometric effects, surface roughness decreases the strength of the depletion interaction. In this study, we demonstrate both by Monte Carlo simulations and experiments that it is possible to generate enough difference in attraction strength to induce phase separation in smooth particles but not in rough particles. Roughness was induced by coating smooth patticles with smaller spherical colloids; We indicate how effective potentials can be obtained through simulations and how the interplay between gravity and the depletion interaction with a flat container wall can be used, to obtain a simple measure of the interaction strengths as a function of roughness.