Recently, logic gates based on multiresponsive hydrogel Systems are attractive because of their potential biological applications.,A quite simple supramolecular hydrogel co-assembled from phenylalanine-based amphiphile (LPP2) and bis(pyridinyl) derivative (AP) is constructed. The co-assembled hydrogel exhibited a macroscopic gel-sol transition in response to four distinct input Stimuli: temperature, acid, base, and light. A set of techniques including microscopic, spectroscopic, and theological measurements demonstrate this performance and confirm that the hydrogel is formed through intermolecular hydrogen bonds between amide/pyridine moieties and carbonyl groups. On the basis Of its mutiple-stimulus responsiveness, installing gel-based supramolecular logic gates (OR and XOR) is achieved. It may promote the possibility to develop smart soft materials, such as gels, that can be used as tools releasing a drug quantitatively by rational design and fine control of the external stimuli.