Biocompatible and three-dimensional hybrid of salicylic acid (SA)-doped polypyrrole (PPy) and alginate (Alg) was synthesized and employed as a dual-stimuli responsive drug delivery platform. The PPy-Alg hybrid combined the electro-responsive feature of PPy and pH-sensitive feature of Alg. Releasing behaviors of the hybrid using SA as the model drug were investigated at different applied potentials and pHs. Finally, two commonly used mathematical models, Higuchi and Korsmeyer-Peppas model, were employed to understand the release kinetics, respectively, demonstrating that the release is controlled by Fickian diffusion. (C) 2016 The Electrochemical Society. All rights reserved.