We report here the rational design of the first chlorin-based nanoscale Metal organic framework (NMOF), DBC-UiO, with Much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DC ligands in DBC-UiO led to a 13 fun red, shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystal, stability, porosity, and nanoplate morphology 61 DBP-UiO, DBC-UiO sensitizes more efficient O-1(2) generation and exhibits significantly enhanced photo, dynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its, improved photophysical properties. Both apoptosis and immunogenic tell death contributed to killing of cancer cells in DBC-UiO-induced PDT.