The synthetic procedures of polyacryloylsulfadiazine were searched by DCC and Acid Cholride methods. Polymeric drug was synthesized by Acid Chloride method in high yield but DCC method in low yield. The antimicrobial activities of polymeric drug was investigated in terms of minimum inhibitory concentrations by the common twofold dilution technique. Polymeric drug revealed an excellent antimicrobial activity against Bacillus subtilis , Staphyloccus aureus , Micrococcus luteus , Klebsiella pueumouiae.