Lead-free single crystal, (K, Na, Li)(Nb, Ta)O-3:Mn, was successfully grown using top-seeded solution growth method. Complete matrix of dielectric, piezoelectric, and elastic constants for [001](C) poled single crystal was determined. The piezoelectric coefficient d(33) measured by the resonance method was 545pC/N, which is almost three times that of its ceramic counterpart. The values measured by the Berlincourt meter and strain-field curve were even higher. The differences were assumed to relate with the different extrinsic contributions of domain wall vibration and domain wall translation during the measurements by different approaches, where the intrinsic contribution (on the order of 539pm/V) was supposed to be the same. The crystal has ultrahigh electromechanical coupling factor (k(33) 95%) and high ultrasound velocity, which make it promising for high-frequency medical transducer applications.