To evaluate the effects of the bed geometry on the scale-up of fixed bed extractors and on the cost of supercritical extracts from Baccharis dracunculifolia leaves (local name in Brazil: alecrim-do-campo), supercritical CO2 (scCO(2)) extraction curves at 50 degrees C and 300 bar at different heights (H) and bed diameter (D), at HID ratio ranging from 1.86 to 5.2 were obtained. The global yield in all experiments was around 4.6%, and the scale-up criterion adopted was maintain constant the solvent flux. Five phenolic compounds of interest, caffeic acid, p-coumaric acid, trans-cinnamic acid, artepillin C, and kaempferide were quantified by high-performance liquid chromatography. The fractions exhibited high kaempferide levels, which varied from 29.07 to 46.47 mg kaempferide per gram of extract. The optimal manufacturing cost has been estimated at US $ 171.12/kg at 80 min, which shows the possibility of obtaining B. dracunculifolia extracts at an industrial level. (C) 2015 Elsevier B.V. All rights reserved.