This paper presents new concepts and methods for regulator configuration design for stable and unstable multivariable systems. Nowadays the self-definitions of dynamic relative gain rarely consider the interaction influences of closed-loop controllers, and the interaction measurement can be also showed from the effects from controlled variables to manipulated variables through closed-loop controllers. Model Predictive Control (MPC) is an important multivariable centralized control strategy; by means of SFPC (State Feedback Predictive Control) and MGPC (Multivariable Generalized Predictive Control), two closed-loop interaction analysis methods are first put forward. Based on the control rate optimized, two inverse normalized gain arrays are obtained from SFPC and MGPC which show the dynamic effects of controlled Variables on manipulated variables. With the inverse normalized gain arrays, the regulator configuration design of unstable systems can be carried out due to the effect of multivariable centralized control. Finally the advantages and effectiveness of proposed interaction analysis approaches are highlighted via several examples. (C) 2015 Elsevier Ltd. All rights reserved.