In this study, a novel catalytic hollow fibre membrane microreactor (CHFMMR) was developed using a micro-structured La0.6Sr0.4Co0.2Fe0.8O3-delta(LSCF) hollow fibre as an oxygen separation membrane as well as a functional substrate for in-situ deposition of a Bi1.5Y0.3Sm0.2O3-delta, (BYS) catalyst using a sol-gel method for oxidative coupling of methane (OCM) reaction. A nano-thickness BYS catalytic layer (300-500 nm) was successfully deposited onto the microchannel walls throughout the whole hollow fibre. The differences in the OCM performances between the in-situ sol-gel prepared CHFMMR and a washcoat CHFMMR are highlighted. The performance of such CHFMMR is found to be strongly dependent on the properties of BYS and the reaction conditions. When the particle size of BYS was reduced to nano-sizes and was uniformly dispersed, the performance of such CHFMMRs changes drastically, in which higher oxygen permeation rate and methane conversion were obtained. A decrease in residence time was observed to give a better C2+ selectivity and C2+ yield, achieving a maximum value of 79% and 39%, respectively at 900 degrees C. To the best of our knowledge, the C2+ yield obtained in this study is the highest value reported so far. The C2+ productivity rate of the in-situ design CHFMIV1R was observed to be nearly four times higher than that of the washcoat CHFMMR clue to the better accessibility of reactants towards lattice/active site of the uniform BYS catalytic layer. (C) 2015 Elsevier B.V. All rights reserved.