A highly selective and stable catalyst based on Pt nanoparticles confined in Mesoporous TiO2-SiO2 frameworks were prepared and employed for selective hydrogenation of cinnamaldehyde to cinnamyl alcohol. The as-prepared Pt/MesoTiO(2)-SiO2-M catalyst displayed excellent selectivity to cinnamyl alcohol (around 91%) at nearly complete conversion. Ti2+ and stronger metal-support interaction (SMSI) played key roles on the adsorption behavior of cinnamaldehyde and activation of C=O bonds. The existence of amorphous SiO2 and mixed TiO2 phases (anatase and rutile) was helpful for the formation of Ti2+ sites and SMSI. The electron-enriched Pt surfaces and the formed Pt-TiOx system benefited the enhanced activity and selectivity. (C) 2015 Elsevier Inc. All rights reserved.