The oxidative dehydrogenation of propane was studied using mixed catalsts of molybdeum, vanadium, and Niobium. Catalytic activities of oxidative dehyerogenation was improved by adding vanadium at constant Mo/Mb ratio. Mo₁V_0.4Nb_0.2 showed highest activity with good selectivity. This catalyst has low crystalinity and has relatively small amount of active oxygen in reation temperature.