A population balance model using a standard method of moments (S - gamma) in an Eulerian-Eulerian framework has been used for oil and brine two-phase flow simulations in pipelines. Results have been compared to both numerical and experimental data from the literature. The effects of the forces constituting the momentum transfer term at the interphase between droplets and the continuous phase (drag, lift, turbulent dispersion and virtual mass), turbulence modelling, break-up and coalescence parameters are analysed; they are shown to be important for droplet mean diameter evolution. It has been demonstrated that a correct combination of models and parameters improves (47% for the best case) simulated results when compared to experimental data. Interactions between the different components of the whole model are discussed and their corresponding effects on the droplet diameter predictions are explained. In particular, the addition of the lift force tends to push the droplet toward the walls of the computational domain where turbulence and shear stress are the strongest, therefore leading to an increased break-up rate. Based on the findings of this study, recommendations for further population balance-based modelling with a standard method of moments are provided. (C) 2015 Elsevier Ltd. All rights reserved.