The adaptive stabilisation is investigated for a class of coupled partial differential equation-ordinary differential equation systems with parametric uncertainties. The presence of the uncertainties makes the systems under investigation essentially different from those in the existing literature, and moreover it results in the incapability of the existing methods. Motivated by the related works, an infinite-dimensional backstepping transformation is first introduced to transform the original system into a pivotal target system, which makes the control design and performance analysis much convenient. Then, by utilising Lyapunov method and some adaptive techniques, an adaptive stabilising controller is successfully constructed, which guarantees that all the closed-loop system states are bounded while the original system states converge to zero. A simulation example is provided to validate the proposed method.