Methyl valerate (VANE), also known as methyl pentanoate, is a methyl ester of pentanoic acid (valeric acid). VAME is usually used as a fragrance in the production of beauty care, soap, and laundry detergents. High purity VANE can also be used as a kind of plasticizer. This study presents design details of the process for the manufacture of VAME. A reactive distillation column (RDC) is used in the production process to overcome equilibrium limitation of the esterification reaction. There is no bottom outlet of this RDC. Both products, VAME and water, are withdrawn from the distillate of RDC and then can be separated by two strippers and a decanter. A thermally coupled design is then developed to reduce the remixing effect in the rectifying section of the RDC. The simulation results show that 30% energy saving can be achieved by using the proposed thermally coupled configuration, but only 17% of total annual costs can be saved due to the use of a compressor. Control strategies of both conventional and thermally coupled configurations in neat design are investigated. The simulation results show that a thermally. coupled configuration can reject disturbances faster with smaller steady state deviations from the specifications of the VAME product.