This paper presents a new approach to event-triggered control for nonlinear uncertain systems by using the notion of input-to-state stability (ISS) and the nonlinear small-gain theorem. The contribution of this paper is threefold. First, it is proved that infinitely fast sampling can be avoided if the system is input-to-state stabilizable with the sampling error as the external input and the corresponding ISS gain is locally Lipschitz. No assumption on the existence of known ISS-Lyapunov functions is made in the discussions. Moreover, the forward completeness problem with event-triggered control is studied systematically by using ISS small-gain arguments. Second, the proposed approach gives rise to a new self-triggered sampling strategy for a class of nonlinear systems subject to external disturbances. If an upper bound of the external disturbance is known, then the closed-loop system can be designed to be robust to the external disturbance, and moreover, the system state globally asymptotically converges to the origin if the external disturbance decays to zero. Third, a new design method is developed for event-triggered control of nonlinear uncertain systems in the strict-feedback form. It is particularly shown that the ISS gain with the sampling error as the input can be designed to satisfy the proposed condition for event-triggered control and self-triggered control.