Accurate predictions of the thermodynamic properties of binary mixtures, especially in the critical region, are essential for many chemical process designs. In this study, based on the predictive crossover volume translation SRK equation of state (VTSRK EoS) presented in previous work, the crossover VTSRK EoS for binary mixtures was developed. Composition-dependent mixing rules with one adjustable binary interaction parameter, kg, were used for the crossover equation to simplify the crossover EoS. The applicability of the crossver EoS was verified against two kinds of binary mixtures, including alkane + alkane and CO2 + alkane mixtures, because of their wide applications. For the alkane + alkane mixtures with similar intermolecular interactions, the k(ij) in the vdW-1 mixing rules was set to zero which makes the calculation predictive. For the CO2 + alkane mixtures which have large difference between intermolecular interactions, the vapor liquid equilibrium (VLE) and single phase p rho T properties were calculated using kij obtained from VLE or p rho T experimental data at one temperature. The crossover VTSRK EoS gives better VLE and p rho T representations than the VTSRK EoS, especially in the critical region. (C) 2015 Elsevier B.V. All rights reserved.