The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous effort to develop novel antibiotics with new modes of action. We recently reported that ABP-d HC-cecropin A exhibited strong antibacterial and antifungal activity, making it a candidate antibiotic substitute. In this study, beta-cyclodextrin (beta-CD) combined with ABP-dHC-cecropin A enhanced the physical and chemical properties of ABP-dHC-cecropin A but did not significantly decrease its antibacterial activity. Thus, beta-CD/ABP-dHC-cecropin A should be considered a novel antibacterial drug. We used beta-CD/ABP-dHC-cecropin A as an anti-Agrobacterium compound to supplementtransgenic poplar medium. Sideeffects of the inclusion complex had little impact on plantgrowth. Thus, beta-CD/ABP-dHCcecropin A may be used as traditional antibiotics forpoplar transplantation with greater antibbacterial effects. (C) 2015 Elsevier Inc. All rights reserved.