This article examines the electricity generation potential from the mass burn application of as-derived and pre-processed municipal solid wastes in Greece, based on the experience gained in Europe and the USA under the Greek National Plan for Waste Management. The results showed that it is feasible to use the latter in existing power plants that are properly equipped for handling volatile metal and dioxin emissions. Athens, Thessaloniki, Thessaly, and Western Greece require regional Waste-to-Energy facilities for as-derived and pre-processed wastes. Implementation of such a plan will reduce fossil fuel consumption and greenhouse gas emissions.