Reverse osmosis desalination plants require both thermal and electrical energies in order to produce water. As Photovoltaic Thermal panels are able to provide the two energies, they become suitable to supply reverse osmosis plants mainly while installed in remote areas. Autonomous based desalination plants must be optimally sized to meet the criteria related to the reverse osmosis operating temperature, the plant autonomy, the needed water, etc. This paper presents a sizing approach for Photovoltaic Thermal collectors supplying reverse osmosis desalination plant to compute the optimal surface of Photovoltaic Thermal collectors and the tank volume with respect to the operating criteria. The approach is composed of three optimization consideration steps: the monthly average data, the fulfillment of the water need and a three day of autonomy for the water tank volume. The algorithm is tested for a case of study of 10 ha of tomato irrigation. The results converged to 700 m(2) of Photovoltaic Thermal collector's surface and 3000 m(3) of water tank volume. (C) 2015 Elsevier Ltd. All rights reserved.