Interaction of an antipsychotic agent, aripiprazole, with calf thymus double stranded deoxyribonucleic acid, ct-dsDNA, was investigated by differential pulse voltammetry (using two methods; interaction on the dsDNA modified electrode surface and in solution phase) and UV-VIS spectrophotometry. The binding constant between dsDNA and aripiprazole, K, about 3 x 10(5) M (1) was obtained spectrophotometrically in 0.1 M acetate buffer, at pH 4.7. Moreover, the DNA-drug association interaction was confirmed by the differential pulse (DP) voltammetric and spectrophotometric investigations of the systems aripiprazole - polyGuanine (polyG) and aripiprazole - polyAdenine (polyA) in solution phase. The interaction between aripiprazole and damaged ct-dsDNA was also investigated using differential pulse voltammetry. (C) 2015 Elsevier Ltd. All rights reserved.