Large-scale microalgae cultivations for CO2 bio-sequestration from power plants can be an alternative process to conventional technologies if the capital investments associated with carbon capture, transport and storage can be reduced or avoided. In order to counterbalance the costs required to operate massive microalgae cultivations, it is necessary to create additional revenues through biomass sales. This manuscript examines the techno-economics of microalgae cultivations for the integration with three power plant technologies using an artificial neural network model. The economics are estimated using the net present value approach. The assessment is carried out at photosynthesis efficiencies ranging from 2% to 6%. The sensitivity assessment shows microalgae selling prices in the range of $440-10281t at a photosynthetic efficiency of 4% for low and high cost scenarios in order to achieve an electricity price similar to that from a conventional power plant without a CO2 capture and storage. (C) 2015 Elsevier Ltd. All rights reserved.