An iron-based metal-organic framework Fe3O(BPDC)(3) was synthesized, and was characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), atomic absorption spectrophotometry (AAS), and nitrogen physisorption measurements. The Fe3O(BPDC)(3) exhibited high activity in the one-pot oxidative synthesis of quinazolinones directly from alcohols and 2-aminobenzamides. The combination of a catalytic amount of the Fe3O(BPDC)(3) as catalyst, tert-butyl hydroperoxide as the oxidant, and DMSO as solvent led to the formation of quinazolinones in high yields. The Fe3O(BPDC)(3) catalyst could be recovered and reused several times without a significant degradation in catalytic activity. The fact that quinazolinones could be prepared directly from alcohols instead of using the unstable aldehydes via a one-pot procedure under heterogeneous catalysis conditions would offer advantages over conventional approaches. To the best of our knowledge, the one-pot oxidative formation of quinazolinones under heterogeneous catalysis conditions was not previously mentioned in the literature. (C) 2015 Elsevier B.V. All rights reserved.