Promoted Fe2O3-Al2O3-CuO (FAC) chromium-free catalysts were prepared for high-temperature water-gas shift reactions and characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller method (BET), temperature-programmed reduction (TPR), and transmission electron microscopy (TEM) techniques. The catalytic results revealed that among the investigated promoted catalysts with Ce, La, Zn, Y, and Mn as promoters, the Mn-promoted sample showed higher activity compared to the other promoted catalysts. Increasing the Mn content improved the surface area and catalytic activity. The FAC catalyst promoted with a high Mn content exhibited maximum activity and relatively high stability in high-temperature water-gas shift reaction.