The methanol-to-olefins reaction (MTO) was studied in a small-scale fluidized-bed reactor over synthesized silicoaluminophosphate (SAPO-34) catalysts. Mesoporous nanocrystalline SAPO-34 molecular sieves were synthesized hydrothermally by ultrasonic and microwave-assisted aging processes in the presence of hexadecyltrimethylammonium bromide (CTAB) and tetradecyldimethyl(3-trimethoxysilylpropyl)ammonium chloride (TPOAC) as surfactant agents. The Box-Behnken experimental design method was applied to determine the optimum operating parameters of this process conducted in the fluidized-bed reactor. The optimum conditions in terms of reaction temperature, ratio of inlet gas velocity to minimum fluidizing velocity, and MeOH weight fraction were evaluated.