The direct catalytic thermo-catalytic transformation of wood in presence of molecular hydrogen has been demonstrated. The resulting organic liquid consists of saturated alkanes and aromatics and was obtained with a yield up to 30 wt.%. Importantly, the oxygen content is about 3 wt.% (<5 wt.% required for bio-fuel formulation) and has a Higher Heating Value of 41 MJ kg(-1) which is very close to standard diesel (44 MJ kg-1) used in automotive fuel. The catalysts comprise multi-functional Cu-Ru supported on Cs exchanged heteropolyacid (H3PW12O40 and H3PMo12O40), featuring depolymerisation, deoxygenation and hydrogenation in a single batch reactor. Current results present an alternative approach to convert highly oxygenated lignocellulosic biomass to a low oxygenated organic liquid suitable as additives in biofuels, in one step and one reactor. (C) 2014 Elsevier B.V. All rights reserved.