In this work, a biorefinery system including castor bean seeds and microalgae is used as a case study to evaluate the integration of second and third generation biorefineries. A biorefinery concept was applied for the combined production of polyol, ethylene-glycol, omega-3 acid, biodiesel, methanol and heat and power from castor bean and microalgae. Castor bean cake and microalgae paste were used to feed a biomass-fired system (BIGCC), where part of CO2 produced in flue gas is captured and employed as substrate for microalgae growth. To evaluate the performance of this biorefinery concept three scenarios based on different levels of mass and energy integration were modeled and assessed from technoeconomic and environmental points of view. The scenario with the best economic and environmental performances was the one including full mass integration, full heat integration, and cogeneration scheme. (C) 2015 Elsevier Ltd. All rights reserved.