The Portezuelo Formation is part of a red bed sequence in the Neuquen Basin assigned to the Neuquen Group (lower Cenomanian middle Campanian). In outcrops of the Portezuelo Formation in the Barda Gonzalez region, iron oxide and hydroxide cements are only preserved in the less permeable claystone layers. Paleomigration of hydrocarbons and formation waters along the most permeable layers bleached the rocks due to partial to total dissolution of cements and grains and formation of several authigenic minerals: (1) montmorillonite and pyrite in the medium- to fine-grained sandstones and mudstones, and (2) multistage calcite and pyrite in the coarse-grained sandstones and conglomerates. The delta(ScDT)-Sc-34 (Canyon Diablo troilite) of -24.4 to 60%0 values in pyrite point to microbial reduction of a sulfate precursor. The oxidation of hydrocarbons and fluctuations in pH and carbon dioxide pressure caused by organic acids resulted in multiple stages of dissolution and precipitation of calcite. Calcite crystals host hydrocarbon-bearing fluid inclusions (+/- pyrite) with variable fluorescence color, indicating that hydrocarbon composition changed with time. The intermediate delta(CpDB)-Cp-13 (Peedee belemnite) (-8.11%0 to 8.52700) and delta(18)opDB(9.76 to 9.83700) isotope composition of calcites may have resulted from mixtures of C-13-rich CO2 after the dissolution of local calcrete with C-13-poor CO2 from oxidizing hydrocarbons. This contribution provides for the first time key information to predict the distribution of authigenic minerals in reservoir rocks in the basin and improves understanding of the diagenetic history of the Portezuelo Formation.