As one of the most abundant natural materials in nature, cellulose has revealed enormous potential for the construction of functional materials thanks to its sustainability, non-toxicity, biocompatibility, and biodegradability. Among many fascinating applications, functional surfaces based on cellulose-derived materials have attracted increasing interest recently, as platforms for diagnostics, sensoring, robust catalysis, water treatment, ultrafiltration, and anti-microbial surfaces. This mini-review attempts to cover the general methodology for the fabrication of functional cellulose surface and a few popular applications including bioactive and non-adhesive (i.e., anti-fouling and anti-microbial) surfaces.