화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.33, 33-41, January, 2016
DOI10.1016/j.jiec.2015.07.022  Export Citation
Surface modification of coralline scaffold for the improvement of biocompatibility and bioactivity of osteoblast
Yong-Won Yoo, Gyeong Ju Park1, and Woo Kul Lee†
  • Lab for Biomaterials and Tissue Engineering, Department of Chemical Engineering, College of Engineering, Dankook University, Yongin, South Korea
  • 1Department of Oral Histology, College of Dentistry, Dankook University, Cheonan, South Korea
E-mail:
Coral is a marine invertebrate consisting of calcium carbonate and used as orthopedic implants due to porous structure and mechanical properties. Its chemical composition, however, can cause rapid degradation and inflammatory response upon implantation. In this study, a surface modification method is developed for coralline scaffold using calcium phosphate (CP) to improve the biocompatibility and osteoblast bioactivity. The physicochemical properties of the scaffolds were evaluated. In vitro investigation demonstrates that the CP coating promoted the osteoblastic differentiation and mineralization. In vivo histological assessment revealed not only reduction in inflammatory response but increase in collagen synthesis in the CP-coated coralline scaffold.
Keywords:Coral;Degradable scaffold;Osteoblast;Proliferation;Differentiation;In vivo histology
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