Large scale synthesis of surface-enhanced Raman scattering nanoprobes with high reproducibility and long-term stability

Hyung-Mo Kim; Sinyoung Jeong; Eunil Hahm; Jaehi Kim; Myeong Geun Cha; Kyoung-Min Kim; Homan Kang; San Kyeong; Xuan-Hung Pham; Yoon-Sik Lee; Dae Hong Jeong; Bong-Hyun Jun

Journal of Industrial and Engineering Chemistry, Vol.33, 22-27, January, 2016

DOI10.1016/j.jiec.2015.09.035 Export Citation

Large scale synthesis of surface-enhanced Raman scattering nanoprobes with high reproducibility and long-term stability

Hyung-Mo Kim, Sinyoung Jeong¹, Eunil Hahm, Jaehi Kim², Myeong Geun Cha¹, Kyoung-Min Kim³, Homan Kang⁴, San Kyeong², Xuan-Hung Pham, Yoon-Sik Lee², Dae Hong Jeong^{1, †}, and Bong-Hyun Jun^†

Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea
¹Department of Chemistry Education, Seoul National University, Seoul 151-742, Republic of Korea
²School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea
³BeadTech, Institute for Chemical Processes, Seoul 151-744, Republic of Korea
⁴Department of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-744, Republic of Korea

E-mail:,

We were successful developed a facile and large-scale synthesis of SERS dots with high reproducibility and long-term stability. Nine kinds of SERS dots with representative and selective Raman bands were fabricated, allowing for simultaneous detection of multiple SERS dots. High sensitivity of SERS dots was demonstrated by analyzing single particles and show sufficient sensitivity to detect a single particle with average enhancement factor in the order of 1.0 × 10 5. Also, SERS dots were stabilized for 300 h. These features suggest that the SERS dots can be utilized as a targeting agent in practical applications.

Keywords:SERS tagging materials;Large scale;Scale-up;Silica nanoparticles;Silver nanoparticles

[References]

Willets KA, Van Duyne RP, Annu. Rev. Phys. Chem., 58, 267 (2007)
Cao YWC, Jin RC, Mirkin CA, Science, 297, 1536 (2002)
Graham D, Mallinder BJ, Whitcombe D, Watson ND, Smith WE, Anal. Chem., 74, 1069 (2002)
Abalde-Cela S, Abell C, Alvarez-Puebla RA, Liz-Marzan LM, J. Phys. Chem. Lett., 5, 73 (2014)
Kang H, Jeong S, Park Y, Yim J, Jun BH, Kyeong S, Yang JK, Kim G, Hong S, Lee LP, Kim JH, Lee HY, Jeong DH, Lee YS, Adv. Funct. Mater., 23, 3719 (2013)
Wang YS, Polavarapu L, Liz-Marzan LM, ACS Appl. Mater. Interfaces, 6, 21798 (2014)
Peng F, Su YY, Zhong YL, Fan CH, Lee ST, He Y, Acc. Chem. Res., 47, 612 (2014)
Jeong S, Kim YI, Kang H, Kim G, Cha MG, Chang H, Jung KO, Kim YH, Jun BH, Do WH, Lee YS, Youn H, Lee YS, Kang KW, Lee DS, Jeong DH, Sci. Rep., 5, 9455 (2015)
Li JM, Wei C, Ma WF, An Q, Guo J, Hu J, Wang CC, J. Mater. Chem., 22, 12100 (2012)
Shah KW, Sreethawong T, Liu SH, Zhang SY, Tan LS, Han MY, Nanoscale, 6, 11273 (2014)
Jiang C, Liu R, Han G, Zhang Z, Chem. Commun., 49, 6647 (2013)
Li JF, Huang YF, Ding Y, Yang ZL, Li SB, Zhou XS, Fan FR, Zhang W, Zhou ZY, Wu DY, Ren B, Wang ZL, Tian ZQ, Nature, 464, 392 (2010)
Kim JH, Kim JS, Choi H, Lee SM, Jun BH, Yu KN, Kuk E, Kim YK, Jeong DH, Cho MH, Lee YS, Anal. Chem., 78, 6967 (2006)
Jun BH, Noh MS, Kim J, Kim G, Kang H, Kim MS, Seo YT, Baek J, Kim JH, Park J, Kim S, Kim YK, Hyeon T, Cho MH, Jeong DH, Lee YS, Small, 6, 119 (2010)
Mir-Simon B, Reche-Perez I, Guerrini L, Pazos-Perez N, Alvarez-Puebla RA, Chem. Mater., 27, 950 (2015)
Wustholz KL, Henry AI, McMahon JM, Freeman RG, Valley N, Piotti ME, Natan MJ, Schatz GC, Van Duyne RP, J. Am. Chem. Soc., 132(31), 10903 (2010)
Chen G, Wang Y, Yang MX, Xu J, Goh SJ, Pan M, Chen HY, J. Am. Chem. Soc., 132(11), 3644 (2010)
Liu S, Jiang C, Yang B, Zhang Z, Han M, RSC Adv., 4, 42358 (2014)
Zhang L, Jiang C, Zhang Z, Nanoscale, 5, 3773 (2013)
Han Y, Liu S, Liu B, Jiang C, Zhang Z, RSC Adv., 4, 2776 (2014)
Woo MA, Lee SM, Kim G, Baek J, Noh MS, Kim JE, Park SJ, Minai-Tehrani A, Park SC, Seo YT, Kim YK, Lee YS, Jeong DH, Cho MH, Anal. Chem., 81, 1008 (2009)
Kim JH, Kang H, Kim S, Jun BH, Kang T, Chae J, Jeong S, Kim J, Jeong DH, Lee YS, Chem. Commun., 47, 2306 (2011)
Zhang ZM, Liu JF, Liu R, Sun JF, Wei GH, Anal. Chem., 86, 7286 (2014)
Tantra R, Brown RJC, Milton MJT, J. Raman Spectrosc., 38, 1469 (2007)
Stober W, Fink A, Bohn E, J. Colloid Interface Sci., 26, 62 (1968)
Jiang P, Deng K, Fichou D, Xie SS, Nion A, Wang C, Langmuir, 25(9), 5012 (2009)
Talley CE, Jackson JB, Oubre C, Grady NK, Hollars CW, Lane SM, Huser TR, Nordlander P, Halas NJ, Nano Lett., 5, 1569 (2005)
Lee M, Kang YL, Rho WY, Kyeong S, Jeong S, Jeong C, Chung WJ, Kim HM, Kang H, Lee YS, RSC Adv., 5, 21050 (2015)
Kang H, Kang T, Kim S, Kim JH, Jun BH, Chae J, Park J, Jeong DH, Lee YS, J. Nanosci. Nanothechnol., 11, 579 (2011)
Li XL, Zhang JH, Xu WQ, Jia HY, Wang X, Yang B, Zhao B, Li BF, Ozaki Y, Langmuir, 19(10), 4285 (2003)

[Referenced By]

[Related Articles]

[1] Willets KA, Van Duyne RP, Annu. Rev. Phys. Chem., 58, 267 (2007)

[2] Cao YWC, Jin RC, Mirkin CA, Science, 297, 1536 (2002)

[3] Graham D, Mallinder BJ, Whitcombe D, Watson ND, Smith WE, Anal. Chem., 74, 1069 (2002)

[4] Abalde-Cela S, Abell C, Alvarez-Puebla RA, Liz-Marzan LM, J. Phys. Chem. Lett., 5, 73 (2014)

[5] Kang H, Jeong S, Park Y, Yim J, Jun BH, Kyeong S, Yang JK, Kim G, Hong S, Lee LP, Kim JH, Lee HY, Jeong DH, Lee YS, Adv. Funct. Mater., 23, 3719 (2013)

[6] Wang YS, Polavarapu L, Liz-Marzan LM, ACS Appl. Mater. Interfaces, 6, 21798 (2014)

[7] Peng F, Su YY, Zhong YL, Fan CH, Lee ST, He Y, Acc. Chem. Res., 47, 612 (2014)

[8] Jeong S, Kim YI, Kang H, Kim G, Cha MG, Chang H, Jung KO, Kim YH, Jun BH, Do WH, Lee YS, Youn H, Lee YS, Kang KW, Lee DS, Jeong DH, Sci. Rep., 5, 9455 (2015)

[9] Li JM, Wei C, Ma WF, An Q, Guo J, Hu J, Wang CC, J. Mater. Chem., 22, 12100 (2012)

[10] Shah KW, Sreethawong T, Liu SH, Zhang SY, Tan LS, Han MY, Nanoscale, 6, 11273 (2014)

[11] Jiang C, Liu R, Han G, Zhang Z, Chem. Commun., 49, 6647 (2013)

[12] Li JF, Huang YF, Ding Y, Yang ZL, Li SB, Zhou XS, Fan FR, Zhang W, Zhou ZY, Wu DY, Ren B, Wang ZL, Tian ZQ, Nature, 464, 392 (2010)

[13] Kim JH, Kim JS, Choi H, Lee SM, Jun BH, Yu KN, Kuk E, Kim YK, Jeong DH, Cho MH, Lee YS, Anal. Chem., 78, 6967 (2006)

[14] Jun BH, Noh MS, Kim J, Kim G, Kang H, Kim MS, Seo YT, Baek J, Kim JH, Park J, Kim S, Kim YK, Hyeon T, Cho MH, Jeong DH, Lee YS, Small, 6, 119 (2010)

[15] Mir-Simon B, Reche-Perez I, Guerrini L, Pazos-Perez N, Alvarez-Puebla RA, Chem. Mater., 27, 950 (2015)

[16] Wustholz KL, Henry AI, McMahon JM, Freeman RG, Valley N, Piotti ME, Natan MJ, Schatz GC, Van Duyne RP, J. Am. Chem. Soc., 132(31), 10903 (2010)

[17] Chen G, Wang Y, Yang MX, Xu J, Goh SJ, Pan M, Chen HY, J. Am. Chem. Soc., 132(11), 3644 (2010)

[18] Liu S, Jiang C, Yang B, Zhang Z, Han M, RSC Adv., 4, 42358 (2014)

[19] Zhang L, Jiang C, Zhang Z, Nanoscale, 5, 3773 (2013)

[20] Han Y, Liu S, Liu B, Jiang C, Zhang Z, RSC Adv., 4, 2776 (2014)

[21] Woo MA, Lee SM, Kim G, Baek J, Noh MS, Kim JE, Park SJ, Minai-Tehrani A, Park SC, Seo YT, Kim YK, Lee YS, Jeong DH, Cho MH, Anal. Chem., 81, 1008 (2009)

[22] Kim JH, Kang H, Kim S, Jun BH, Kang T, Chae J, Jeong S, Kim J, Jeong DH, Lee YS, Chem. Commun., 47, 2306 (2011)

[23] Zhang ZM, Liu JF, Liu R, Sun JF, Wei GH, Anal. Chem., 86, 7286 (2014)

[24] Tantra R, Brown RJC, Milton MJT, J. Raman Spectrosc., 38, 1469 (2007)

[25] Stober W, Fink A, Bohn E, J. Colloid Interface Sci., 26, 62 (1968)

[26] Jiang P, Deng K, Fichou D, Xie SS, Nion A, Wang C, Langmuir, 25(9), 5012 (2009)

[27] Talley CE, Jackson JB, Oubre C, Grady NK, Hollars CW, Lane SM, Huser TR, Nordlander P, Halas NJ, Nano Lett., 5, 1569 (2005)

[28] Lee M, Kang YL, Rho WY, Kyeong S, Jeong S, Jeong C, Chung WJ, Kim HM, Kang H, Lee YS, RSC Adv., 5, 21050 (2015)

[29] Kang H, Kang T, Kim S, Kim JH, Jun BH, Chae J, Park J, Jeong DH, Lee YS, J. Nanosci. Nanothechnol., 11, 579 (2011)

[30] Li XL, Zhang JH, Xu WQ, Jia HY, Wang X, Yang B, Zhao B, Li BF, Ozaki Y, Langmuir, 19(10), 4285 (2003)