반상호침투 구조체 형성을 이용한 막대형 양자물질의 분산과 안정화

리스티아나 옥타비아; 김성진; 김종형; 박해인; 이창환; 곽민석; Listiana Oktavia; Seong-Jin Kim; Jong Hyung Kim; Haein Park; Peter Chang-Whan Lee; Minseok Kwak

Polymer(Korea), Vol.40, No.1, 130-134, January, 2016

DOI10.7317/pk.2016.40.1.130 Export Citation

반상호침투 구조체 형성을 이용한 막대형 양자물질의 분산과 안정화

Dispersion and Stabilization of Quantum Rod Through Semi-interpenetrating Network Formation

리스티아나 옥타비아, 김성진¹, 김종형², 박해인, 이창환^{1, †}, 곽민석^†

부경대학교 화학과
¹서울아산병원
²(주)이리도스

Listiana Oktavia, Seong-Jin Kim¹, Jong Hyung Kim², Haein Park, Peter Chang-Whan Lee^{1, †}, and Minseok Kwak^†

Department of Chemistry, Pukyong University, Busan 48513, Korea
¹Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, Korea
²Iridos Ltd., Ulsan 45010, Korea

E-mail:,

초록

PEO-b-PPO-b-PEO를 기본 구조로 한 F127, L64 등의 pluronic은 수용액에서 미세상분리에 의하여 자기조립하고 그 중심부에 소수성의 분자들을 담지할 수 있는 응용가능성이 높은 고분자이다. 수십 나노 미터의 길이를 가진 막대모양 나노결정인 막대형 양자물질(quantum rod; QR) 콜로이드를 소수성 상호작용으로 담지한 뒤, 곧바로 반상호침투 구조체를 제조하여 장기간 형광 세기의 현저한 저하가 없는 안정한 유-무기 복합 나노소재를 수월하게 만들 수 있다. 우리가 제조한 F127-QR-sIPN 나노구조체는 표면이 poly(ethylene oxide)(PEO)로 둘러싸여 생체적합성 이 우수하며 형광특성을 가진 QR이 세포섭취됨에 따라 형광 이미징도 가능함을 보였다.

Pluronics (e.g. F127 and L64) are linear triblock copolymers capable of loading hydrophobic moieties within the core of aggregates via micro-phase separation. We demonstrate semi-interpenetrating network formation of organicinorganic hybrid composites consist of quantum rod (QR) firmly encapsulated by F127. The stabilized nanoobjects are stable for a long period. Furthermore, we report that QR-IPN is promising material applicable in fluorescent cell-imaging with guaranteed biocompatibility.

Keywords:encapsulation;hybrids;fluorescence;biocompatible;cell imaging

[References]

IUPAC, Compendium of Chemical Terminology, 2nd ed. (the “Gold Book”), Compiled by McNaught AD, Wilkinson A, Blackwell Scientific Publications, Oxford, 1997.
Petrov P, Bozukov M, Tsevanov CB, J. Mater. Chem., 15, 1481 (2005)
Carey GH, Abdelhady AL, Ning Z, Thon SM, Bakri OM, Sargent EH, Chem. Rev., 15, 1101 (2015)
Banerjee A, Grazon C, Nadal B, Pons T, Krishnan TY, Bioconjugate Chem., 26, 1582 (2015)
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Yong KT, Hu R, Roy I, Ding H, Vathy LA, Bergey EJ, Mizuma M, Maitra A, Prasad PN, J. Am. Chem. Soc., 1, 710 (2009)
Jia G, Xu S, Wang A, J. Mater. Chem. C, 3, 8284 (2015)
Talapin DV, Nelson JH, Shevchenko EV, Aloni S, Sadtler B, Alivisatos AP, Nano Lett., 7, 2951 (2007)
Liu L, Yong KT, Roy I, Law WC, Ye L, Liu J, Liu J, Kumar R, Zhang X, Prasad PN, Theranostics, 2, 705 (2012)
Zhu ZJ, Yeh YC, Tang R, Yan B, Tamayo J, Vachet RW, Rotello VM, Nat. Chem., 3, 963 (2011)
Heo SH, Jang MJ, Kim DG, Jeong YI, Jang MK, Nah JW, Polym.(Korea), 31(5), 454 (2007)
Khatun Z, Nurunnabi M, Lee DY, Kim YJ, BYun Y, Cho KJ, Lee YK, Macromol. Res., 23(7), 686 (2015)
Kim HG, Jo SH, Yeon SM, Kim KH, Chung JW, Park TW, Byun Y, Lee EH, Park YI, Jung YW, Macromol. Res., 21(12), 1355 (2013)

[Referenced By]

[1] IUPAC, Compendium of Chemical Terminology, 2nd ed. (the “Gold Book”), Compiled by McNaught AD, Wilkinson A, Blackwell Scientific Publications, Oxford, 1997.

[2] Petrov P, Bozukov M, Tsevanov CB, J. Mater. Chem., 15, 1481 (2005)

[3] Carey GH, Abdelhady AL, Ning Z, Thon SM, Bakri OM, Sargent EH, Chem. Rev., 15, 1101 (2015)

[4] Banerjee A, Grazon C, Nadal B, Pons T, Krishnan TY, Bioconjugate Chem., 26, 1582 (2015)

[5] Naahidi S, Jafari M, Edalat F, Raymond K, Khademhosseini A, Chen P, J. Control. Release, 166, 182 (2013)

[6] Yong KT, Hu R, Roy I, Ding H, Vathy LA, Bergey EJ, Mizuma M, Maitra A, Prasad PN, J. Am. Chem. Soc., 1, 710 (2009)

[7] Jia G, Xu S, Wang A, J. Mater. Chem. C, 3, 8284 (2015)

[8] Talapin DV, Nelson JH, Shevchenko EV, Aloni S, Sadtler B, Alivisatos AP, Nano Lett., 7, 2951 (2007)

[9] Liu L, Yong KT, Roy I, Law WC, Ye L, Liu J, Liu J, Kumar R, Zhang X, Prasad PN, Theranostics, 2, 705 (2012)

[10] Zhu ZJ, Yeh YC, Tang R, Yan B, Tamayo J, Vachet RW, Rotello VM, Nat. Chem., 3, 963 (2011)

[11] Heo SH, Jang MJ, Kim DG, Jeong YI, Jang MK, Nah JW, Polym.(Korea), 31(5), 454 (2007)

[12] Khatun Z, Nurunnabi M, Lee DY, Kim YJ, BYun Y, Cho KJ, Lee YK, Macromol. Res., 23(7), 686 (2015)

[13] Kim HG, Jo SH, Yeon SM, Kim KH, Chung JW, Park TW, Byun Y, Lee EH, Park YI, Jung YW, Macromol. Res., 21(12), 1355 (2013)