화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.40, No.1, 101-108, January, 2016
DOI10.7317/pk.2016.40.1.101  Export Citation
합성고무와 카르복시메틸셀룰로오스(CMC) 나트륨을 이용한 하이드로콜로이드형 창상치료재의 제조 및 평가
Fabrication and Evaluation of Hydrocolloid Wound Dressing Using Synthetic Rubber and Sodium Carboxymethylcellulose (CMC)
김원일1, 2, 이승욱1, 박재진2, 고영광3, 박원호4, 조동환3, 권오형3, †
  • 1금오공과대학교 고분자공학과
  • 2㈜원바이오젠
  • 3금오공과대학교 고분자공학과, 이승욱
  • 4충남대학교 유기소재·섬유시스템공학과
Won Il Kim1, 2, Seung Wook Lee1, 3, Jae Jin Park2, Young-Gwang Ko1, 3, Won Ho Park4, Donghwan Cho1, 3, and Oh Hyeong Kwon1, 3, †
  • 1Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea
  • 2R&D Center, Wonbiogen Co., Ltd., Gumi 39372, Korea
  • 3, Korea
  • 4Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 34134, Korea
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초록
본 연구에서는 합성고무와 sodium carboxymethylcellulose(CMC)를 서로 다른 조성비로 혼합하여 하이드로콜로이드형 창상치료재를 제조하였다. 얻어진 창상치료재는 CMC 함량이 높아질수록 신장률과 점착력은 감소하는 경향을 나타내는 반면에 흡수도는 높아지는 것을 확인할 수 있었다. 최적의 조성으로 판단된 40%의 CMC를 함유하는 하이드로콜로이드의 신장률, 점착력, 흡수도 및 투습도는 각각 400% 이상, 1.78 kgf/25 mm, 327% 및 547 g/m2/day임을 확인하였다. 제조된 하이드로콜로이드의 세포배양실험 결과 세포적합성이 우수하였고, 동물실험 결과 대조군에 비하여 우수한 창상치유 효과를 보였으며, 피부자극성시험 결과 자극이 없는 것으로 나타났다. 따라서 본 연구에서 제조한 하이드로콜로이드는 의료용 창상치료재로서의 적용 가능성이 높음을 알 수 있었다.
In this study, hydrocolloid wound dressing was fabricated from synthetic rubbers and sodium carboxymethylcellulose (CMC) with different composition ratios. Hydrocolloid wound dressing fabricated in this study showed increased absorptivity, decreased elongation at break and adhesive forces with increasing content of CMC. Hydrocolloid with 40% of CMC is determined as the optimum composition and its elongation at break, adhesive force, water absorptivity and moisture vapor transmission rate were more than 400%, 1.78 kgf/25 mm, 327% and 547 g/m2/day, respectively. Fabricated hydrocolloid was found to have the best property on the in vitro cell culture test, and in vivo animal study showed excellent wound healing effect than control groups. Also there was no stimulation in the skin irritation test. Therefore, it is confirmed that hydrocolloid has the broad application possibility as wound healing materials.
Keywords:hydrocolloid;synthetic rubber;CMC;natural polymers;wound healing;dressing material
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