Photo-crosslinkable chitosan hydrogel as a bioadhesive for esophageal stents

Chun Gwon Park; Catherine Shasteen; Zohreh Amoozgar; Joonyoung Park; Se-Na Kim; Ji Eun Lee; Min Jae Lee; Yoorock Suh; Hyun Kwang Seok; Yoon Yeo; Young Bin Choy

Macromolecular Research, Vol.23, No.9, 882-884, September, 2015

DOI10.1007/s13233-015-3115-0 Export Citation

Photo-crosslinkable chitosan hydrogel as a bioadhesive for esophageal stents

Chun Gwon Park¹, Catherine Shasteen², Zohreh Amoozgar³, Joonyoung Park³, Se-Na Kim⁴, Ji Eun Lee⁴, Min Jae Lee⁵, Yoorock Suh⁵, Hyun Kwang Seok⁶, Yoon Yeo^{3, †}, and Young Bin Choy^{1, 4, †}

¹Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 110-799, Korea
²Department of Materials Science and Engineering, College of Engineering, Seoul National University, Seoul, 152-742, Korea
³Department of Industrial and Physical Pharmacy and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA
⁴Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 152-742, Korea
⁵Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, 110-799, Korea
⁶Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, 136-7912, Korea

E-mail:,

Esophagealstents are clinically used as a therapy for dysphagia to mechanically open the esophageal passageway to allow nutritional intake and improve quality of life. However, migrantion of the stents within the esophagus is problematic, causing warious complications. Therfore, in this study, wesuggest a biocompatible chitosan conjugated with 4-azidobenzoic readily form an adhesive hydrogel upon UV illumination, which showed comparable work of adhesion to Carbopol 934P gel and improved adhesiveness between the surfaces of a silicone-covered stent and esophageal tissue.

[References]

Herszenyi L, Tulassay Z, Eur. Rev. Med. Pharmacol. Sci., 14, 249 (2010)
Pennathur A, Gibson MK, Jobe BA, Luketich JD, Lancet, 381, 400 (2013)
Bernard W, Christopher P, World Cancer Report 2014, WHO Press, World Health Organization, Lyon, 2014.
Enzinger PC, Mayer RJ, N. Engl. J. Med., 349, 2241 (2003)
Homs MYV, Steyerberg EW, Eijkenboom WMH, Tilanus HW, Stalpers LJA, Bartelsman JFWM, van Lanschot JJB, Wijrdeman HK, Mulder CJJ, Reinders JG, Boot H, Aleman BMP, Kuipers E, Siersema PD, Lancet, 364, 1497 (2004)
Hill JL, Norberg HP, Smith MD, Young JA, Reyes HM, J. Pediatr. Surg., 11, 443 (1976)
Diamantis G, Scarpa M, Bocus P, Realdon S, Castoro C, Ancona E, Battaglia G, World J. Gastroenterol., 17, 144 (2011)
Sharma P, Kozarek R, Am. J. Gastroenterol., 105, 258 (2010)
Irani S, Kozarek R, Tech. Gastrointest. Endosc., 12, 178 (2010)
Didden P, Spaander M, Bruno M, Kuipers E, Curr. Gastroenterol. Rep., 15, 1 (2013)
Vakil N, Morris AI, Marcon N, Segalin A, Peracchia A, Bethge N, Zuccaro G, Bosco JJ, Jones WF, Am. J. Gastroenterol., 96, 1791 (2001)
Uitdehaag MJ, van Hooft JE, Verschuur EML, Repici A, Steyerberg EW, Fockens P, Kuipers EJ, Siersema PD, Gastrointest. Endosc., 70, 1082 (2009)
Hirdes MMC, Siersema PD, Vleggaar FP, Gastrointest. Endosc., 75, 712 (2012)
Bakken JC, Song LMWK, de Groen PC, Baron TH, Gastrointest. Endosc., 72, 712 (2010)
Eloubeidi MA, Talreja JP, Lopes TL, Al-Awabdy BS, Shami VM, Kahaleh M, Gastrointest. Endosc., 73, 673 (2011)
Uitdehaag MJ, Siersema PD, Spaander MCW, Vleggaar FP, Verschuur EML, Steyerberg EW, Kuipers EJ, Gastrointest. Endosc., 71, 600 (2010)
Talreja JP, Eloubeidi MA, Sauer BG, Al-Awabdy BS, Lopes T, Kahaleh M, Shami VM, Surg. Endosc., 26, 1664 (2012)
Ono K, Saito Y, Yura H, Ishikawa K, Kurita A, Akaike T, Ishihara M, J. Biomed. Mater. Res., 49, 289 (2000)
Rickett TA, Amoozgar Z, Tuchek CA, Park J, Yeo Y, Shi RY, Biomacromolecules, 12(1), 57 (2011)
Amoozgar Z, Rickett T, Park J, Tuchek C, Shi RY, Yeo Y, Acta Biomater., 8, 1849 (2012)
Prasitsilp M, Jenwithisuk R, Kongsuwan K, Damrongchai N, Watts P, J. Mater. Sci. -Mater. Med., 11, 773 (2000)
Muzzarelli RAA, Carbohydr. Polym., 20, 7 (1993)
Ono K, Ishihara M, Ozeki Y, Deguchi H, Sato M, Saito Y, Yura H, Sato M, Kikuchi M, Kurita A, Maehara T, Surgery, 130, 844 (2001)
Henriksen I, Green KL, Smart JD, Smistad G, Karlsen J, Int. J. Pharm., 145, 231 (1996)
Bowman K, Leong KW, Int. J. Nanomed., 1, 117 (2006)

[1] Herszenyi L, Tulassay Z, Eur. Rev. Med. Pharmacol. Sci., 14, 249 (2010)

[2] Pennathur A, Gibson MK, Jobe BA, Luketich JD, Lancet, 381, 400 (2013)

[3] Bernard W, Christopher P, World Cancer Report 2014, WHO Press, World Health Organization, Lyon, 2014.

[4] Enzinger PC, Mayer RJ, N. Engl. J. Med., 349, 2241 (2003)

[5] Homs MYV, Steyerberg EW, Eijkenboom WMH, Tilanus HW, Stalpers LJA, Bartelsman JFWM, van Lanschot JJB, Wijrdeman HK, Mulder CJJ, Reinders JG, Boot H, Aleman BMP, Kuipers E, Siersema PD, Lancet, 364, 1497 (2004)

[6] Hill JL, Norberg HP, Smith MD, Young JA, Reyes HM, J. Pediatr. Surg., 11, 443 (1976)

[7] Diamantis G, Scarpa M, Bocus P, Realdon S, Castoro C, Ancona E, Battaglia G, World J. Gastroenterol., 17, 144 (2011)

[8] Sharma P, Kozarek R, Am. J. Gastroenterol., 105, 258 (2010)

[9] Irani S, Kozarek R, Tech. Gastrointest. Endosc., 12, 178 (2010)

[10] Didden P, Spaander M, Bruno M, Kuipers E, Curr. Gastroenterol. Rep., 15, 1 (2013)

[11] Vakil N, Morris AI, Marcon N, Segalin A, Peracchia A, Bethge N, Zuccaro G, Bosco JJ, Jones WF, Am. J. Gastroenterol., 96, 1791 (2001)

[12] Uitdehaag MJ, van Hooft JE, Verschuur EML, Repici A, Steyerberg EW, Fockens P, Kuipers EJ, Siersema PD, Gastrointest. Endosc., 70, 1082 (2009)

[13] Hirdes MMC, Siersema PD, Vleggaar FP, Gastrointest. Endosc., 75, 712 (2012)

[14] Bakken JC, Song LMWK, de Groen PC, Baron TH, Gastrointest. Endosc., 72, 712 (2010)

[15] Eloubeidi MA, Talreja JP, Lopes TL, Al-Awabdy BS, Shami VM, Kahaleh M, Gastrointest. Endosc., 73, 673 (2011)

[16] Uitdehaag MJ, Siersema PD, Spaander MCW, Vleggaar FP, Verschuur EML, Steyerberg EW, Kuipers EJ, Gastrointest. Endosc., 71, 600 (2010)

[17] Talreja JP, Eloubeidi MA, Sauer BG, Al-Awabdy BS, Lopes T, Kahaleh M, Shami VM, Surg. Endosc., 26, 1664 (2012)

[18] Ono K, Saito Y, Yura H, Ishikawa K, Kurita A, Akaike T, Ishihara M, J. Biomed. Mater. Res., 49, 289 (2000)

[19] Rickett TA, Amoozgar Z, Tuchek CA, Park J, Yeo Y, Shi RY, Biomacromolecules, 12(1), 57 (2011)

[20] Amoozgar Z, Rickett T, Park J, Tuchek C, Shi RY, Yeo Y, Acta Biomater., 8, 1849 (2012)

[21] Prasitsilp M, Jenwithisuk R, Kongsuwan K, Damrongchai N, Watts P, J. Mater. Sci. -Mater. Med., 11, 773 (2000)

[22] Muzzarelli RAA, Carbohydr. Polym., 20, 7 (1993)

[23] Ono K, Ishihara M, Ozeki Y, Deguchi H, Sato M, Saito Y, Yura H, Sato M, Kikuchi M, Kurita A, Maehara T, Surgery, 130, 844 (2001)

[24] Henriksen I, Green KL, Smart JD, Smistad G, Karlsen J, Int. J. Pharm., 145, 231 (1996)

[25] Bowman K, Leong KW, Int. J. Nanomed., 1, 117 (2006)