UPLC-MS method for the simultaneous determination of naproxen, fluvastatin and ibuprofen in waste water samples

Saikh M. Wabaidur; Zeid A. AlOthman; Masoom R. Siddiqui; Kazi Mohsin; Leda G. Bousiakou; George A. Karikas

Journal of Industrial and Engineering Chemistry, Vol.24, 302-307, April, 2015

DOI10.1016/j.jiec.2014.09.046 Export Citation

UPLC-MS method for the simultaneous determination of naproxen, fluvastatin and ibuprofen in waste water samples

Saikh M. Wabaidur^†, Zeid A. AlOthman, Masoom R. Siddiqui, Kazi Mohsin^{1, †}, Leda G. Bousiakou², and George A. Karikas³

Advanced Materials Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
¹Kayyali Chair for Pharmaceutical Industries, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
²Department of Physics and Astronomy, King Saud University, Riyadh 11451, Saudi Arabia
³Department of Medical Laboratories Technology, Technological Educational Institute of Athens, Athens, Greece

E-mail:,

Ultra performance liquid chromatography?mass spectrometry (UPLC-MS) method has been developed for the simultaneous determination of pharmaceuticals in industrial waste water samples. The binary mobile phase was used a mixture of acetonitrile and 0.1% aqueous solution of formic acid at a flow rate of 0.4 ml min?1. Identification and quantitation of the analyzed drug samples were carried out using mass spectrometer equipped with electrospray ionization source operated in negative ionization mode. The linear range of the proposed method was found to be in the range of 18?270 ng ml?1 for all drugs with limit of detection in the range of 1.25 to 1.89 ng ml-1.

Keywords:Pharmaceuticals;Pollutants;Liquid chromatography;Mass spectrometry

[References]

Adatia A, Rainsford KD, Kean WF, J. Pharm. Pharmacol., 64, 626 (2012)
Apstein CS, Vogel WM, J. Pharmacol. Exp. Ther., 220, 167 (1982)
French L, Am. Fam. Physician, 15, 285 (2005)
Bader T, Fazili J, Madhoun M, Aston C, Hughes D, Rizvi S, Seres K, Hasan M, Am. J. Gastroenterol., 103, 1383 (2008)
Daughton CG, Ternes AT, Environ. Health Perspect., 107(107), 907 (1999)
Dubey SP, Dwivedi AD, Lee C, Kwon YN, Sillanpaa M, Ma LQ, J. Ind. Eng. Chem., 20(3), 1126 (2014)
Charinpanitkul T, Tanthapanichakoon W, Kulvanich P, Kim KS, J. Ind. Eng. Chem., 14(5), 661 (2008)
Haberer T, Dunnbier U, Reilich C, Stan H, J. Fresenius Environ. Bull., 6(438) (1997)
Reddersen K, Haberer T, Dunnbier U, Chemosphere, 49, 539 (2002)
Ternes TA, Environ. Sci. Technol., 36, 3855 (2002)
Haberer T, Schmidt-Baumler K, Stan H, J. Acta Hydroch. Hydrob., 26, 272 (1998)
Garrison AW, Pope JD, Allen FR, Analysis of organic compounds in domestic wastewater, in: Keith CH (Ed.), Identification and Analysis of Organic Pollutants in Water, Ann Arbor Science, Michigan, USA, 1976, pp. 517-566.
Richardson ML, Bowron JM, J. Pharm. Pharmacol., 37, 1 (1985)
Rogers IH, Birtwell IK, Kruznyski GM, Water Pollut. Res. J. Can., 21, 187 (1986)
Stumpf M, Ternes T, Haberer K, Seel P, Baumann W, Vom Wasser, 86, 291 (1996)
Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M, Environ. Sci. Technol., 32, 1549 (1998)
Siddiqui MR, AlOthman ZA, Rahman N, Arab. J. Chem., http://dx.doi.org/10.1016/j.arabjc.2013.04.016. (2013)
Alothman ZA, Rahman N, Siddiqui MR, Rev. Adv. Sci. Eng., 2, 155 (2013)
Ternes T, Hirsch R, Mueller J, Haberer K, J. Fresenius Anal. Chem., 362, 329 (1998)
Ternes T, Bonerz M, Schmidt T, J. Chromatogr. A, 938, 175 (2001)
Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT, Environ. Sci. Technol., 36, 1202 (2002)
Kummerer K, Pharmaceuticals in the Environment, 2nd ed., Springer-Verlag, New York, 2004.
Macia A, Borrull F, Calull M, Benavente F, Hernandez E, Sanz-Nebot V, Barbosa J, Aguilar G, J. Sep. Sci., 31, 872 (2008)
Cardoso JL, Lanchote VL, Pereira MP, de Moraes NV, Lepera JS, J. Sep. Sci., 37, 944 (2014)
Wabaidur SM, Alothman ZA, Khan MR, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 108, 20 (2013)
Petrovic M, Hernando MD, Dıaz-Cruz MS, Barcelo D, J. Chromatogr. A, 1067, 1 (2005)
Loffler D, Ternes TA, J. Chromatogr. A, 1021, 133 (2003)
Hilton MJ, Thomas KV, J. Chromatogr. A, 1015, 129 (2003)
Briscoe CJ, Stiles MR, Hage DS, J. Pharm. Biomed. Anal., 44, 484 (2007)
Alothman ZA, Wabaidur SM, Khan MR, Ghafar AA, Habila MA, Yacine BHA, J. Sep. Sci., 35, 2892 (2012)
Khan MR, Alothman ZA, Ghafar AA, Wabaidur SM, J. Sep. Sci., 36, 572 (2013)

[1] Adatia A, Rainsford KD, Kean WF, J. Pharm. Pharmacol., 64, 626 (2012)

[2] Apstein CS, Vogel WM, J. Pharmacol. Exp. Ther., 220, 167 (1982)

[3] French L, Am. Fam. Physician, 15, 285 (2005)

[4] Bader T, Fazili J, Madhoun M, Aston C, Hughes D, Rizvi S, Seres K, Hasan M, Am. J. Gastroenterol., 103, 1383 (2008)

[5] Daughton CG, Ternes AT, Environ. Health Perspect., 107(107), 907 (1999)

[6] Dubey SP, Dwivedi AD, Lee C, Kwon YN, Sillanpaa M, Ma LQ, J. Ind. Eng. Chem., 20(3), 1126 (2014)

[7] Charinpanitkul T, Tanthapanichakoon W, Kulvanich P, Kim KS, J. Ind. Eng. Chem., 14(5), 661 (2008)

[8] Haberer T, Dunnbier U, Reilich C, Stan H, J. Fresenius Environ. Bull., 6(438) (1997)

[9] Reddersen K, Haberer T, Dunnbier U, Chemosphere, 49, 539 (2002)

[10] Ternes TA, Environ. Sci. Technol., 36, 3855 (2002)

[11] Haberer T, Schmidt-Baumler K, Stan H, J. Acta Hydroch. Hydrob., 26, 272 (1998)

[12] Garrison AW, Pope JD, Allen FR, Analysis of organic compounds in domestic wastewater, in: Keith CH (Ed.), Identification and Analysis of Organic Pollutants in Water, Ann Arbor Science, Michigan, USA, 1976, pp. 517-566.

[13] Richardson ML, Bowron JM, J. Pharm. Pharmacol., 37, 1 (1985)

[14] Rogers IH, Birtwell IK, Kruznyski GM, Water Pollut. Res. J. Can., 21, 187 (1986)

[15] Stumpf M, Ternes T, Haberer K, Seel P, Baumann W, Vom Wasser, 86, 291 (1996)

[16] Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M, Environ. Sci. Technol., 32, 1549 (1998)

[17] Siddiqui MR, AlOthman ZA, Rahman N, Arab. J. Chem., http://dx.doi.org/10.1016/j.arabjc.2013.04.016. (2013)

[18] Alothman ZA, Rahman N, Siddiqui MR, Rev. Adv. Sci. Eng., 2, 155 (2013)

[19] Ternes T, Hirsch R, Mueller J, Haberer K, J. Fresenius Anal. Chem., 362, 329 (1998)

[20] Ternes T, Bonerz M, Schmidt T, J. Chromatogr. A, 938, 175 (2001)

[21] Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT, Environ. Sci. Technol., 36, 1202 (2002)

[22] Kummerer K, Pharmaceuticals in the Environment, 2nd ed., Springer-Verlag, New York, 2004.

[23] Macia A, Borrull F, Calull M, Benavente F, Hernandez E, Sanz-Nebot V, Barbosa J, Aguilar G, J. Sep. Sci., 31, 872 (2008)

[24] Cardoso JL, Lanchote VL, Pereira MP, de Moraes NV, Lepera JS, J. Sep. Sci., 37, 944 (2014)

[25] Wabaidur SM, Alothman ZA, Khan MR, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 108, 20 (2013)

[26] Petrovic M, Hernando MD, Dıaz-Cruz MS, Barcelo D, J. Chromatogr. A, 1067, 1 (2005)

[27] Loffler D, Ternes TA, J. Chromatogr. A, 1021, 133 (2003)

[28] Hilton MJ, Thomas KV, J. Chromatogr. A, 1015, 129 (2003)

[29] Briscoe CJ, Stiles MR, Hage DS, J. Pharm. Biomed. Anal., 44, 484 (2007)

[30] Alothman ZA, Wabaidur SM, Khan MR, Ghafar AA, Habila MA, Yacine BHA, J. Sep. Sci., 35, 2892 (2012)

[31] Khan MR, Alothman ZA, Ghafar AA, Wabaidur SM, J. Sep. Sci., 36, 572 (2013)