A computational fluid dynamic model has been developed for a modified Denver flotation cell used in laboratory batch tests. The model incorporates fundamental aspects of bubble-particle interactions including bubble-particle collision, attachment and detachment. Model predictions are compared against carefully planned laboratory experiments with narrowly-sized spherical ballotini. Flotation results for different impeller speeds have been obtained for a constant air flow into the cell. The particles have been made hydrophobic by methylation with trimethylchlorosilane. For a given particle size, the results from the model and experimental work indicate that there is an optimum stirring speed that produces a good compromise between attachment and detachment rates in the cell for flotation. For less hydrophobic particles, a lower stirring speed is beneficial in having a longer contact time because of the longer induction time required for attachment. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.